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Perspective: Navigating US Healthcare

A healthtech series: pioneering experts discuss cutting-edge solutions and shaping healthcare advancements.

IN THIS EPISODE

We have with us a visionary tech and healthcare leader Mahek Chatrapati to get into the transformative power of AI and data analytics in Healthcare. It’s evident throughout the conversation that AI can only help empower human intelligence, enhance efficiency and improve patient care. Learn how AI is streamlining communication between healthcare professionals, ensuring seamless collaboration across the ecosystem

GUEST

A dynamic and results-driven professional with a strong passion for technology, healthcare, and innovation. He has a proven track record of leading engineering projects at the largest refinery in the US, showcasing extensive expertise in optimization, operational excellence, efficiency, and distribution. His outstanding leadership abilities have been demonstrated through successful initiatives with industry giants such as Blue Origin, SpaceX, and BP. Currently serving as the CEO of DocNexus, a pioneering health tech startup, Mahek continues to push boundaries in the healthcare industry. His visionary leadership and expertise make him an invaluable asset to any organization seeking to drive growth, efficiency, and transformation in today’s dynamic business landscape.

EPISODE TRANSCRIPT

Ratnadeep Bhattacharjee: Hello and welcome to an insightful episode of “Leader’s  Perspective- Navigating US Healthcare”. I am your host, Ratnadeep Bhattacharjee ,  Co-Founder of TechVariable and I’m deeply committed to exploring the frontiers of  digital transformation.  

Today we are venturing into a domain where the stakes are incredibly high and the  potential for positive change is massive in the world of healthcare. Our guest today is no  longer a stranger in the field, he’s someone who is at the forefront of driving significant  change and has garnered and harnessed the power of technology particularly, AI and  advanced data analytics to revolutionize healthcare.  

I’m thrilled to introduce Mahek Chhatrapati who not only made pivotal strikes at the  crossroads of Healthcare and Technology but also led ambitious engineering projects at  the largest refinery in the U.S. Mahek is now changing the way we perceive healthcare  delivery and patient care at the top mixes by enabling access to insights from millions of  scientific publications clinical trials and claims within seconds.  

Our conversation today will shed light on how AI and advanced data analytics are  reshaping the healthcare landscape, the challenges and ethical implications of AI  development and deployment, and also what the future actually holds in this exciting  space. So get ready as we dive into this fascinating topic and explore the transformative  potential of AI in healthcare. Let’s get started.  

Welcome Mahek.  

Mahek Chhatrapati: Yes thank you so much for having me on board.  

Ratnadeep Bhattacharjee: So your career trajectory is a remarkable one, transitioning  from leading crucial engineering projects at the largest refinery in the U.S., to shaking  up the global healthcare landscape with AI-driven tools at DocNexus. Can you tell us about that defining moment that steered you toward this intersection of healthcare and  AI?  

Mahek Chhatrapati: Growing up in the 90s, there wasn’t this wave of AI. It was kind of  where everyone was in the traditional roles. I started off my career excited to make a  huge impact on the world. So I started off working at a chemical refinery. We delivered  oxygen, nitrogen, hydrogen, and a variety of things to Aerospace clients, petrochemical  clients, and even hospitals all across Dallas, Chicago, and different markets.  

My interest in artificial intelligence, even cloud computing, all began during my time at  business school and then carried forward during my time at Amazon. I started to see a  lot of things that were happening, like getting exposure at a global scale to what’s going on across computer vision. Now everyone’s talking about ChatGPT but even the basic  NLP models, determining what sentiment does. A lot of these things have a huge  impact.  

So for me, that was a defining moment. And then for my team at DocNexus, our Chief  Technology Officer, Gordon, and I got together and we realized there was so much  power in what we could potentially do with DocNexus and medical relationships. So we  started creating what we called “knowledge graphs”. It’s like a world where one  healthcare provider is at the center of the circle and then every possible relationship that  the person has is like a node.  

It’s similar to Facebook or LinkedIn, like one degree of separation, two degrees of  separation, but not only looking at friends or your professional network. We started  looking at it in the realm of publications or clinical trials or how many payments you’ve  received from X company. So some of those things really shaped where we are as a  company today and those are some of the things that I found pretty fascinating with AI.  

Ratnadeep Bhattacharjee: It’s an interesting sequel to my next question. It feels like  we are on the precipice of a revolution in healthcare rights with AI and Machine  Learning and technologies like ChatGPT and stuff like that leading the charge. At the  helm of DocNexus, you were at the heart of this transformation. Can you tell us about  one AI implementation that you believe will really disrupt the traditional healthcare  approach?  

Mahek Chhatrapati: I’m not sure if I can cite one specific implementation of AI. There  are so many different advancements you can make. If you look at the life sciences  industry or pharmaceutical industry like at DocNexus, we’re using AI through knowledge  graphs, as I said before, not only looking through external data sources but also internal ones. You can look at large healthcare institutions today like the Mayo Clinic or  Memorial Hermann or MD Anderson who use a lot of generative AI.  

I saw a company called Glass Health that’s doing a lot of innovation focused on  physicians, looking at symptoms that patients are actually feeling and determining what  are some of the treatment pathways to use or what are some of the diagnosis pathways  to actually assess these patients. So there’s a lot of innovation happening not only  across pharma from that lens, but it’s really happening in both the Avenues.

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Ratnadeep Bhattacharjee: So coming to the same point, reflecting on your time in tech  product management, can you shed some light on how AI is reshaping user experience  in healthcare? Maybe share a transformation story that really underlines the ship?  

Mahek Chhatrapati: I would say how is healthcare transforming the industry? I’ve seen  a couple of these examples but one that kind of comes to mind is what we’ve seen with  Google or Mayo Clinic. They’re able to use different AI models to predict how I look at  like mammograms or how I look at different pieces of different information about  patients and predict likelihoods that these patients are feeling right. And so those are  some of the instances that we’ve seen so far. But there’s a variety of other ones kind of  coming along the pathway as well.  

Ratnadeep Bhattacharjee: Have you seen any practical use cases of generative AI or  ChatGPT being used? You’ve already given some examples I understand that but some  that are currently within the scheme of things in the industry but we have not yet  known? I know generative AI is is the buzz now right but we still don’t know its true  potential, to be honest. So how do you how do you really see this technology taking  over healthcare?  

Mahek Chhatrapati: I would say there’s a couple of different models that have been  launched specifically to the healthcare landscape. Some of them are pretty well known  like Med-PaLM 2, a large language model that Google’s developed. It’s one that’s  actually is able to have over an 85 accuracy rates and it’s passed like a variety of  exams. I think it tested itself against the MedMCQA data sets. It scored very highly and  you’re actually able to give it questions similar to what a physician would ask their  patients. And it’s able to determine what is the diagnosis of that patient and what do I  see in the future.  

And actually, one of the most interesting stats that I’ve seen today is that these large  language models are actually even more empathetic than actual physicians in some  cases. So we’re seeing a lot of this coming out. I think one of the more interesting use cases that we’ll see come out over time is that there’s so many hundreds of millions of  clinical notes that are taken every single year. And all those are unstructured data. No  one’s looking through doctors chicken-scratch-handwriting determining what’s useful,  what’s not useful.  

So this is an avenue where I think people are going to start to eventually evaluate this  unstructured data, determining how likely a patient is in terms of getting the following  diagnoses in the future. Are they just like you? Today with AWS’s CloudWatch, you can  check the status of your EC2 instances. Why can’t you check the status of what’s  potentially going to happen to your patient? If they miss this point, I think a lot of these  instances are going to start emerging with generative AI in the future.  

And people are not going to start building their own large language models from  scratch. They’re just going to continue building on top of them. An example of  Med-PaLM 2 is one where you can use it to leverage documents, clinical notes, field  insights and really determine what’s going to happen to patients in the long term.That’s  really what’s going to happen going forward.  

Ratnadeep Bhattacharjee: We have had some fascinating conversations on the power  of data in driving informed decisions. You have been part of this data driven  transformation in healthcare. Can you tell us a story about how data analytics,  especially in combination with AI is changing the way decisions are made in the  healthcare sector?  

Mahek Chhatrapati: If you look at the entire healthcare sector, I think a lot of  companies are starting to experiment with generative AI. They’ve seen that a lot of  these large language models can have a huge amount of impact. There was a lot of  stuff that’s going on with a company like Vertex AI, which is using a lot of deep mind,  which has a lot of protein structure prediction systems. They’re gonna be using it from  that case.  

And we’ve seen a lot of these instances come about across the industry. I think we’re  still in a portion where everyone’s trying to figure out what the exact use cases are,  whether it’s like mining speech, whether it’s mining data from clinical notes, whether it’s  mining information.  

Today at DocNexus, we’re very focused on looking through claims data. We’re looking  through CMS data, publications and trying to match that down to a healthcare provider  and figure out, “Are they the right person to join this ad board?” And so I think the use cases are going to continue developing from that perspective. I have a couple of examples.  

Thinking about healthcare AI across the industry, the first one that I had was related back to image analysis. This is where you’re using and training AI based off different information, whether it’s x-rays, CT scans, MRI scans, you’re using it to determine any abnormalities and make diagnoses. So I know today Google’s actually using that to detect breast cancer within mammograms and it’s able to get a higher accurate score  than some of the human radiologists. We’ve also seen it as well with other large healthcare organizations.  

So the Mayo clinics actually use these different AI models to predict which patients are  going to develop or who are highest probability in terms of getting um like acute kidney injuries. We’ve seen another use case that’s going to be pretty valuable over the long term. It’s within personalized medicine.  

Every single person is very different and so this is where can actually look through a  specific data, my data or even your data, rough and deep. We can look through and  determine what is going to be an individualized treatment plan for that patient based off some of your unique characteristics, and some of your medical history. Some companies today are already at the forefront of this.  

IBM has been actively focused on developing AI models that are focused on personalized medicine. They look at a patient’s genetic data, they determine what are  their personalized treatment options for certain cancers. So those are some of the examples that I think are going to continue developing over time within Big Data, within  the AI landscape. And this is where you can leverage analytics.  

If you can look through a person’s history over time, you can see they have high LDL,  high cholesterol. You can see other parameters and determine what is the best plan for  this individual person? If they also have a high risk of cardiovascular disease, what do I  do then? So we’ll continue seeing these in the long term.  

Ratnadeep Bhattacharjee: These are interesting examples Mahek. Till now, we’ve only talked about AI, data analytics, data engineer, use cases of data, using data for proper healthcare delivery in general. One of the most important aspects that tend to be discussed behind the closed doors is ethics and compliance. There is always a buzzing debate around ethics in AI in healthcare. In your journey, have you encountered any overlooked ethical challenges when deploying AI in healthcare? And how do you see this dynamic kind of change? Or the tension receding a bit between cutting-edge innovation and ethical compliances?  

Mahek Chhatrapati: Today at DocNexus that’s not a problem that we faced predominantly because we’re looking through public data streams and not as much on  an individualized patient perspective. I do see that PII information, especially about  certain patients, is gonna be a compliance issue long term. Training a lot of these  models and then not knowing who’s going to have access to the data that’s available,  within these large language models, could pose concerns.  

I do see a lot of hesitation from a lot of healthcare institutions from adopting such  models today. I think that’s going to be a big point of concern. Having a physician in the  office versus having an AI model taking that data, from a compliance perspective, I do  see a lot of value in the large numbers. I think if an AI model is seen, “Okay this is what  I’ve detected in terms of a colonoscopy” and I’ve detected a polyp like 150 times or  hundreds of thousands of times, it’s going to be able to detect any sort of anomaly  better than any physician or surgeon would.  

But from a complex alliance perspective, it’s like “do I want to expose pictures of my  colon to other folks out there in the ecosystem?” I think that’s something that’s going to  be debated over time. I don’t think I have an answer. And I think it’s too early to tell  what’s going to happen within this landscape across compliance. I think ethics come  into extreme value here.  

What’s ethical, what’s not ethical, it’s going to be up to the judgment. Not only should  these AI models get input from physicians that are out there, but they should get inputs  from other folks as a part the healthcare institution. I think in conjunction with the  physicians and the healthcare institutions, we’ll solely figure out what is like the best  course of action for the patients.  

I think at the end, in the whole four trillion dollar healthcare industry, everyone’s building  very different solutions. Some are facing patients, some are focused on healthcare  institutions, some are focused on life science firms, some are focused on digital  therapeutics, there’s a whole host of things. But everyone’s trying to make the lives of  patients better. So we’ll need to navigate this water fairly and carefully.

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Ratnadeep Bhattacharjee: This understandably is a very debatable topic. There will be  many different connotations and permutations combinations which will kick in when we  discuss these things. Similar to this topic, one of the most debatable or regressed upon  topic is the value of outsourcing in the healthcare industry. Outsourcing a certain portion of the technology to a third party vendor. You cannot ignore outsourcing, you can  probably avoid it, but cannot ignore it.  

So I wanted to understand from you a bit on what your thoughts are and how can  people or how can healthcare companies primarily decide on what to outsource and  how to outsource, most importantly? Can you shed light on what your thoughts are on  that one?  

Mahek Chhatrapati: Whether it’s healthcare or not healthcare, I think outsourcing has a ton of value across the industry. I think it just depends on what you believe as a  company or what some of your core competencies are and what are not. If there’s areas  that are core competencies that you excel in, there’s something proprietary, that’s  something you believe you can build in, else I wouldn’t outsource.  

If there’s other areas where you believe you need expertise, you really feel like some of  these tasks are going to be fairly expensive for your team and you could benefit from outsourcing, I think that’s where companies, whether you’re healthcare or not, or even in engineering, can you can really see value in it? I think that’s one of the things that companies should try to consider when they make this decision.  

Ratnadeep Bhattacharjee: Let’s let’s talk about DocNexus a bit. So DocNexus is harnessing the power of AI to draw insights from a massive corpus of scientific texts,  clinical trials, and more of these, all in seconds. Can you tell us about a real life situation where DocNexus made a tangible difference in healthcare delivery or patient outcomes? And how do you think this rapid excess of information will shape healthcare in the days to come?  

Mahek Chhatrapati: We recently worked with a client across the Alzheimer’s landscape. One of the instances that we saw was Alzheimer’s drugs hadn’t changed in the past 20-25 years. So this is where new drugs are coming to market. It’s harder to measure impact directly across patients. It’s more across “How to get patients access to the right drugs that they need?” and so we’re very upstream of the patient journey.  

We’re at the stages of where companies are coming about. They are actively working  on a product that’s either going through clinical trials, that’s about to go through clinical  trials, that’s about to get FDA clearance, and they’re trying to talk to healthcare  providers across the ecosystem. Whether it’s healthcare providers in India, Asia, Europe  or US, they’re trying to figure out who’s the right healthcare provider that’s going to really support my product all the way through to launch? Or even once the products launch, how are they going to get this in the hands of patients better? 

So one instance that we saw was a large pharmaceutical organization that came to us.  They wanted to figure out who the top experts were across the Alzheimer’s landscape.  We helped determine who these experts were, how they go about engaging with them.  And then we would track every single piece of information about these healthcare  

providers, what are they publishing about, what trials are they actively working on,  which other pharmaceutical organizations have they received payment from, are they any competing interests, and what are they doing across the social media landscape as well.  

Then we even look through claims. We’d look through information on what type of patients are these physicians treating in aggregate? Are they usually treating folks with  Alzheimer’s or dementia or a mix of things from that perspective? Then we would  provide, “Okay, these are some of the experts you should be talking with as you bring  this new product to market because they would have a lot of valuable insights.” And so I think this is where the use cases knowledge graphs are going to become immensely more valuable. Because it’s that physician or even in this case, let’s say it’s a medical concept that’s the center. Alzheimers.  

You now figure out in that inner circle who are the top experts that are globally or nationally known. You can even go regionally and then you can break down locally.  Every market is very different. If someone’s treating me in Iowa versus someone’s treating me in Seattle, I’m gonna go see a very different position. I want to get the best treatment options, who should I be seeing?  

You look at that physician in Iowa or even in Seattle, now you want to figure out what other types of patients are they treating. What are they actively working on? Are they active within academic research? Are they big within industry? Are they getting payments from large pharmaceutical organizations? And how does that tie you? So that’s the picture that we gather at DocNexus.  

Ratnadeep Bhattacharjee: It’s a great product I must say, Mahek. You’re doing great things for healthcare. As we delve into the future I’m sure our listeners are curious about what a world with even tighter integration between AI and Healthcare might look like from where you stand? Mahek, can you share a surprising or counter-intuitive prediction  you may have about the future of AI in Healthcare?  

Mahek Chhatrapati: Across the healthcare landscape, things take time. It’s not going to be where everyone’s talking about ChatGPT, talking about large language models.  We’re talking about implementation. We have to keep in mind that a lot of healthcare 

institutions still use fax machines. We’re still operating in a world that is compliant heavy. It’s going to take years and years before we see a lot of adoption of these models.  

Physicians, surgeons, and a lot of these people aren’t going away. I don’t think healthcare is going to like be a place where jobs are going to be eliminated. I think people are just going to be a lot more efficient. A lot of these tools are going to hopefully help physicians. I think a lot of people think that, “Oh I can use ChatGPT to diagnose my medical conditions. I don’t need to go see a surgeon or a physician.” That’s not the world we’re gonna be in any time soon.  

I think we’re going to be in a world where people even physicians may use these large language models on a regular basis to potentially add to their spectrum of, “Oh these are some additional diagnoses that the patient may have right.” and so that’s the world we’re probably going to be in in the next three to five years, and that’s going to continue developing. And these tools are going to help both patients and physicians long term.  

Ratnadeep Bhattacharjee: I think this is an interesting point that you’ve put across. On similar lines I would say partnerships will play a vital role in this AI Empowered  Healthcare landscape. From your viewpoint, what’s the blueprint for an ideal symbiosis between AI innovators like DocNexus and healthcare providers? How can we create a  supportive and productive ecosystem in this dynamic field?  

Mahek Chhatrapati: I guess between us and more so healthcare providers, the best way to bridge this relationship or the world between healthcare providers and life science firms, is where some healthcare providers are really excited about engaging with pharma but they’ve never engaged with pharma in the past. So they may have developed a ton of expertise across diabetes or Alzheimer’s or specific type of cancer within oncology. So we’re trying to really bridge that Gap.  

We’re trying to get physicians to actually highlight what their field of expertise is based off public data. Also looking through claims data, figure out, “Okay this is the level of expertise for that physician” and then figure out what healthcare provider like or what life science firm is kind of in that cycle. A lot of life science firms are in very different cycles  in terms of drug development. Some products get through clinical trials and phase one,  some get through phase two, some of them like don’t. So trying to figure out what that  right match is between the product that’s getting developed and what type of physicians  are actually treating patients, that’s the bridge that we’re trying to really fill. 

Ratnadeep Bhattacharjee: As we close this enlightening conversation, could you point our listeners to a source that has profoundly influenced your views on AI in Healthcare?  And one parting piece of advice for our listeners to help them navigate this landscape better, the AI centric future of healthcare. So what would be your take on that?  

Mahek Chhatrapati: I can’t point to one specific source. I think there’s a ton of podcasts. There’s a lot of information I personally even use, like ChatGPT regularly, just ask it questions. Whether it’s personal or professional questions, you can use it on a  regular basis and get a lot of insights from there. And then I think as listeners, think about the future of healthcare as we’ve seen in the last year and a half to two years,  we’ve seen it rapidly develop. It’s going to continue to do so. There’s a lot of concerns,  there’s a lot of information that probably still hasn’t been figured out. Compliance, a lot of these things are going to come into play in the near term. We’re going to start seeing this over the next couple years as well.  

I think the one piece of advice I have for the listeners is just be curious. Read as much  as you can about ChatGPT or large language models. Start practicing, try getting into  the tools, whether it’s getting into GPT-4 developer platform, whether it’s downloading the app on your iPhone, try asking any questions. That’s where the models are going to continue getting refined over time. And I think one of the things that we are going to see and I didn’t highlight this before, is we’re going to see a world where hopefully the power of users feedback may improve.  

I think that’s one of the things as these models develop, people are going to say, “Okay,  this is great, ChatGPT this is not great, and that.” Feedback is going to continue refining these models for millions of people and so hopefully everyone out there gets involved,  gets practical, learns. If you have new recommendations feel free to share them with your friends, your peers, and your family, because that’s going to not only make them but yourselves more educated.  

Ratnadeep Bhattacharjee: Well there we have it folks, a truly enriching conversation with none other than Mahek. We have journeyed through the transformative power of AI band advanced data analytics in healthcare, exploring the challenges, ethical considerations, and the vision for a future where technology and healthcare are even more closely interwoven.  

From today’s discussion it’s clear that the marriage of healthcare and AI is not only  inevitable but also crucial in driving patient outcomes and transforming healthcare 

delivery. It’s not every day that we get insights from someone who is at the forefront of such an exciting and important transition. A big thank you Mahek. I think sharing your  insights, and predictions, your work at DocNexus continues to inspire us and give us a  glimpse of the exciting possibilities ahead.  

Remember in this fast evolving digital landscape, it’s conversation like these that keep us informed, challenges our perspectives and ignite our imaginations. Thank you for all for joining us in today’s episode. We look forward to bringing you more thought  provoking discussions in the future. Until next time I am your host Ratnadeep signing off, thank you. 

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This podcast series explores groundbreaking advancements in healthcare technologies and innovations, featuring conversations with pioneering experts who have played a crucial role in shaping and implementing transformative AI-driven solutions within the healthcare industry.

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